Adhesion to fibronectin via α5β1 integrin supports expansion of the megakaryocyte lineage in primary myelofibrosis

Excessive accumulation of extracellular matrix (ECM) is a hallmark of bone marrow (BM) milieu in primary myelofibrosis (PMF). Because cells have the ability to adhere to the surrounding ECM through integrin receptors, we examined the hypothesis that an abnormal ECM-integrin receptor axis contributes...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Matsuura, Shinobu, Thompson, Cristal Reyna, Ng, Seng Kah, Ward, Christina Marie, Karagianni, Aikaterini, Mazzeo, Carla, Malara, Alessandro, Balduini, Alessandra, Ravid, Katya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316217/
https://ncbi.nlm.nih.gov/pubmed/32294178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019004230
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