Irisin modulates genes associated with severe coronavirus disease (COVID-19) outcome in human subcutaneous adipocytes cell culture

Obesity patients are more susceptible to develop COVID-19 severe outcome due to the role of angiotensin-converting enzyme 2 (ACE2) in the viral infection. ACE2 is regulated in the human cells by different genes associated with increased (TLR3, HAT1, HDAC2, KDM5B, SIRT1, RAB1A, FURIN and ADAM10) or d...

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Publicat a:Mol Cell Endocrinol
Autors principals: de Oliveira, Miriane, De Sibio, Maria Teresa, Mathias, Lucas Solla, Rodrigues, Bruna Moretto, Sakalem, Marna Eliana, Nogueira, Célia Regina
Format: Artigo
Idioma:Inglês
Publicat: Elsevier B.V. 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7315947/
https://ncbi.nlm.nih.gov/pubmed/32593740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2020.110917
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