Thymosin alpha 1 (Tα1) reduces the mortality of severe COVID-19 by restoration of lymphocytopenia and reversion of exhausted T cells

BACKGROUND: We previously reported that lymphocytopenia and T cell exhaustion is notable in acute COVID19 patients, especially in aged and severe cases. Thymosin alpha 1 (Tα1) had been used in the treatment of viral infections as an immune response modifier for many years. However, clinical benefits...

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Veröffentlicht in:Clin Infect Dis
Hauptverfasser: Liu, Yueping, Pang, Yue, Hu, Zhenhong, Wu, Ming, Wang, Chenhui, Feng, Zeqing, Mao, Congzheng, Tan, Yingjun, Liu, Ying, Chen, Li, Li, Min, Wang, Gang, Yuan, Zilin, Diao, Bo, Wu, Yuzhang, Chen, Yongwen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
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Major Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314217/
https://ncbi.nlm.nih.gov/pubmed/32442287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciaa630
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