Regenerative potential of prostate luminal cells revealed by single cell analysis

Androgen deprivation is the cornerstone of prostate cancer treatment, resulting in involution of the normal gland to ~90% its original size due to loss of luminal cells. The prostate regenerates when androgen is restored, a process postulated to involve stem cells. Using single cell RNA-sequencing,...

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Publicado en:Science
Autores principales: Karthaus, Wouter R., Hofree, Matan, Choi, Danielle, Linton, Eliot L., Turkekul, Mesruh, Bejnood, Alborz, Carver, Brett, Gopalan, Anuradha, Abida, Wassim, Laudone, Vincent, Biton, Moshe, Chaudhary, Ojasvi, Xu, Tianhao, Masilionis, Ignas, Manova, Katia, Mazutis, Linas, Pe’er, Dana, Regev, Aviv, Sawyers, Charles L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7313621/
https://ncbi.nlm.nih.gov/pubmed/32355025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay0267
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