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Activation of alpha7 nicotinic and NMDA receptors is necessary for performance in a working memory task

RATIONALE: Working memory deficits are present in schizophrenia (SZ) but remain insufficiently resolved by medications. Similar cognitive dysfunctions can be produced acutely in animals by elevating brain levels of kynurenic acid (KYNA). KYNA’s effects may reflect interference with the function of b...

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Publicat a:Psychopharmacology (Berl)
Autors principals: Phenis, David, Vunck, Sarah A., Valentini, Valentina, Arias, Hugo, Schwarcz, Robert, Bruno, John P.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7313359/
https://ncbi.nlm.nih.gov/pubmed/32162104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-020-05495-y
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