CD200 promotes immunosuppression in the pancreatic tumor microenvironment

BACKGROUND: A significant challenge to overcome in pancreatic ductal adenocarcinoma (PDAC) is the profound systemic immunosuppression that renders this disease non-responsive to immunotherapy. Our supporting data provide evidence that CD200, a regulator of myeloid cell activity, is expressed in the...

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Pubblicato in:J Immunother Cancer
Autori principali: Choueiry, Fouad, Torok, Molly, Shakya, Reena, Agrawal, Kriti, Deems, Anna, Benner, Brooke, Hinton, Alice, Shaffer, Jami, Blaser, Bradley W, Noonan, Anne M, Williams, Terence M, Dillhoff, Mary, Conwell, Darwin L, Hart, Phil A, Cruz-Monserrate, Zobeida, Bai, Xue-Feng, Carson III, William E, Mace, Thomas A
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2020
Soggetti:
Basic Tumor Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7312341/
https://ncbi.nlm.nih.gov/pubmed/32581043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2019-000189
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