Dexfenfluramine and Pergolide Cause Heart Valve Disease via Valve Metabolic Reprogramming and Ongoing Matrix Remodeling

Several clinical reports indicate that the use of amphetaminic anorectic drugs or ergot derivatives could cause valvular heart disease (VHD). We sought to investigate whether valvular lesions develop in response to long-term oral administration of these drugs and to identify drug-targeted biological...

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Publicat a:Int J Mol Sci
Autors principals: Oury, Cécile, Maréchal, Patrick, Donis, Nathalie, Hulin, Alexia, Hego, Alexandre, Tridetti, Julien, Nguyen, Mai-Linh, Dulgheru, Raluca, Fillet, Marianne, Nchimi, Alain, Lancellotti, Patrizio
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7312197/
https://ncbi.nlm.nih.gov/pubmed/32503311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21114003
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