IgG4 Autoantibodies Attenuate Systemic Lupus Erythematosus Progression by Suppressing Complement Consumption and Inflammatory Cytokine Production

Pathogenic autoantibodies can cause inflammation and tissue injury in systemic lupus erythematosus (SLE). Although IgG4 is considered non-inflammatory owing to the unique structure of its hinge region, the role of IgG4 autoantibodies in SLE remains largely unknown. The titers of serum anti-nuclear-I...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Pan, Qingjun, Xiao, Haiyan, Shi, Lei, He, Yiming, Cai, Jun, Wu, Jing, Li, Aifen, Ye, Lin, Yang, Chen, Liu, Hua-feng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311789/
https://ncbi.nlm.nih.gov/pubmed/32625200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01047
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