A novel homozygous mutation in WDR19 induces disorganization of microtubules in sperm flagella and nonsyndromic asthenoteratospermia

BACKGROUND: Asthenoteratospermia with multiple morphological abnormalities in the sperm flagella (MMAF) is a significant cause of male infertility. WDR19 is a core component in the IFT-A complex and has a critical role in intraflagellar transport. However, the role of WDR19 mutations in male inferti...

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Pubblicato in:J Assist Reprod Genet
Autori principali: Ni, Xiaoqing, Wang, Jiajia, Lv, Mingrong, Liu, Chunyu, Zhong, Yading, Tian, Shixiong, Wu, Huan, Cheng, Huiru, Gao, Yang, Tan, Qing, Chen, Beili, Li, Qiang, Song, Bing, Wei, Zhaolian, Zhou, Ping, He, Xiaojin, Zhang, Feng, Cao, Yunxia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2020
Soggetti:
Genetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311615/
https://ncbi.nlm.nih.gov/pubmed/32323121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10815-020-01770-1
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