Biodistribution, dosimetry, and temporal signal-to-noise ratio analyses of normal and cancer uptake of [(68)Ga]Ga-P15-041, a gallium-68 labeled bisphosphonate, from first-in-human studies

INTRODUCTION: [(68)Ga]Ga-P15-041 ([(68)Ga]Ga-HBED-CC-BP) is a novel bone-seeking PET radiotracer that can be generator-produced. We undertook a Phase 0/I clinical trial to assess its potential for imaging bone metastases in prostate cancer including assessment of radiotracer biodistribution and dosi...

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Pubblicato in:Nucl Med Biol
Autori principali: Doot, Robert K., Young, Anthony J., Daube-Witherspoon, Margaret E., Alexoff, David, Labban, Kyle J., Lee, Hwan, Wu, Zehui, Zha, Zhihao, Choi, Seok R., Ploessl, Karl H., Schubert, Erin K., Lee, Hsiaoju, Zhu, Lin, Reddin, Janet S., Karp, Joel S., Kung, Hank, Pryma, Daniel A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311273/
https://ncbi.nlm.nih.gov/pubmed/32361089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2020.04.002
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