Direct Antiviral Activity of IFN-Stimulated Genes Is Responsible for Resistance to Paramyxoviruses in ISG15-Deficient Cells

IFNs, produced during viral infections, induce the expression of hundreds of IFN-stimulated genes (ISGs). Some ISGs have specific antiviral activity, whereas others regulate the cellular response. Besides functioning as an antiviral effector, ISG15 is a negative regulator of IFN signaling, and inher...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Holthaus, David, Vasou, Andri, Bamford, Connor G. G., Andrejeva, Jelena, Paulus, Christina, Randall, Richard E., McLauchlan, John, Hughes, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2020
Assuntos:
Innate Immunity and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311202/
https://ncbi.nlm.nih.gov/pubmed/32423918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901472
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