Translational profiling of macrophages infected with Leishmania donovani identifies mTOR- and eIF4A-sensitive immune-related transcripts

The protozoan parasite Leishmania donovani (L. donovani) causes visceral leishmaniasis, a chronic infection which is fatal when untreated. Herein, we investigated whether in addition to altering transcription, L. donovani modulates host mRNA translation to establish a successful infection. Polysome-...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Chaparro, Visnu, Leroux, Louis-Philippe, Masvidal, Laia, Lorent, Julie, Graber, Tyson E., Zimmermann, Aude, Arango Duque, Guillermo, Descoteaux, Albert, Alain, Tommy, Larsson, Ola, Jaramillo, Maritza
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7310862/
https://ncbi.nlm.nih.gov/pubmed/32479529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008291
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