Early prepubertal cyclophosphamide exposure in mice results in long-term loss of ovarian reserve, and impaired embryonic development and blastocyst quality

BACKGROUND: Due to improved treatment, there is an increasing focus on the reproductive potential of survivors of childhood cancer. Cytotoxic chemotherapy accelerates the decline in the number of primordial follicles within the mammalian ovary at all ages, but effects on the developmental potential...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Salian, Sujith Raj, Uppangala, Shubhashree, Cheredath, Aswathi, D’Souza, Fiona, Kalthur, Guruprasad, Nayak, Vinod C., Anderson, Richard A., Adiga, Satish Kumar
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7310698/
https://ncbi.nlm.nih.gov/pubmed/32574203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235140
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