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High-Throughput Screening for Substrate Specificity-Adapted Mutants of the Nisin Dehydratase NisB
[Image: see text] Microbial lanthipeptides are formed by a two-step enzymatic introduction of (methyl)lanthionine rings. A dehydratase catalyzes the dehydration of serine and threonine residues, yielding dehydroalanine and dehydrobutyrine, respectively. Cyclase-catalyzed coupling of the formed dehyd...
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| Publicado no: | ACS Synth Biol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2020
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7309312/ https://ncbi.nlm.nih.gov/pubmed/32374981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssynbio.0c00130 |
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