Akt Inhibition Is Associated With Favorable Immune Profile Changes Within the Tumor Microenvironment of Hormone Receptor Positive, HER2 Negative Breast Cancer

Background: The PI3K/Akt/mTOR pathway in part impacts tumorigenesis through modulation of host immune activity. To assess the effects of Akt inhibition on the tumor micro-environment (TME), we analyzed tumor tissue from patients with operable hormone receptor positive, HER2 negative breast cancer (B...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Marks, Douglas K., Gartrell, Robyn D., El Asmar, Margueritta, Boboila, Shuobo, Hart, Thomas, Lu, Yan, Pan, Qingfei, Yu, Jiyang, Hibshoosh, Hanina, Guo, Hua, Andreopoulou, Eleni, Wiechmann, Lisa, Crew, Katherine, Sparano, Joseph, Hershman, Dawn, Connolly, Eileen, Saenger, Yvonne, Kalinsky, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308467/
https://ncbi.nlm.nih.gov/pubmed/32612958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00968
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