Evidence for a role of RUNX1 as recombinase cofactor for TCRβ rearrangements and pathological deletions in ETV6-RUNX1 ALL

T-cell receptor gene beta (TCRβ) gene rearrangement represents a complex, tightly regulated molecular mechanism involving excision, deletion and recombination of DNA during T-cell development. RUNX1, a well-known transcription factor for T-cell differentiation, has recently been described to act in...

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Publicado no:Sci Rep
Main Authors: Seitz, V., Kleo, K., Dröge, A., Schaper, S., Elezkurtaj, S., Bedjaoui, N., Dimitrova, L., Sommerfeld, A., Berg, E., von der Wall, E., Müller, U., Joosten, M., Lenze, D., Heimesaat, M. M., Baldus, C., Zinser, C., Cieslak, A., Macintyre, E., Stocking, C., Hennig, S., Hummel, M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308335/
https://ncbi.nlm.nih.gov/pubmed/32572036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65744-0
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