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Dual targeting of SREBP2 and ERRα by carnosic acid suppresses RANKL-mediated osteoclastogenesis and prevents ovariectomy-induced bone loss

Osteoporosis develops because of impaired bone formation and/or excessive bone resorption. Several pharmacological treatment of osteoporosis has been developed; however, new treatments are still necessary. Cholesterol and estrogen receptor-related receptor alpha (ERRα) promote osteoclasts formation,...

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Bibliografski detalji
Izdano u:Cell Death Differ
Glavni autori: Zheng, Zu-Guo, Cheng, Hui-Min, Zhou, Ya-Ping, Zhu, Si-Tong, Thu, Pyone Myat, Li, Hui-Jun, Li, Ping, Xu, Xiaojun
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308277/
https://ncbi.nlm.nih.gov/pubmed/31907393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0484-5
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