Type-1 cytokines regulate MMP-9 production and E-cadherin disruption to promote melanocyte loss in vitiligo

Loss of melanocytes is the pathological hallmark of vitiligo, a chronic inflammatory skin depigmenting disorder induced by exaggerated immune response, including autoreactive CD8 T cells producing high levels of type 1 cytokines. However, the interplay between this inflammatory response and melanocy...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Boukhedouni, Nesrine, Martins, Christina, Darrigade, Anne-Sophie, Drullion, Claire, Rambert, Jérôme, Barrault, Christine, Garnier, Julien, Jacquemin, Clément, Thiolat, Denis, Lucchese, Fabienne, Morel, Franck, Ezzedine, Khaled, Taieb, Alain, Bernard, François-Xavier, Seneschal, Julien, Boniface, Katia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308056/
https://ncbi.nlm.nih.gov/pubmed/32369451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.133772
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