T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice

Patients with systemic lupus erythematosus (SLE) present a high incidence of atherosclerosis, which contributes significantly to morbidity and mortality in this autoimmune disease. An impaired balance between regulatory (Treg) and follicular helper (Tfh) CD4(+) T cells is shared by both diseases. Ho...

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Udgivet i:JCI Insight
Main Authors: Li, Wei, Elshikha, Ahmed S., Cornaby, Caleb, Teng, Xiangyu, Abboud, Georges, Brown, Josephine, Zou, Xueyang, Zeumer-Spataro, Leilani, Robusto, Brian, Choi, Seung-Chul, Fredenburg, Kristianna, Major, Amy, Morel, Laurence
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308052/
https://ncbi.nlm.nih.gov/pubmed/32493841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.138274
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