Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments

[Image: see text] “Hot loop” protein segments have variable structure and conformation and contribute crucially to protein–protein interactions. We describe a new hot loop mimicking modality, termed PepNats, in which natural product (NP)-inspired structures are incorporated as conformation-determini...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Guéret, Stéphanie M., Thavam, Sasikala, Carbajo, Rodrigo J., Potowski, Marco, Larsson, Niklas, Dahl, Göran, Dellsén, Anita, Grossmann, Tom N., Plowright, Alleyn T., Valeur, Eric, Lemurell, Malin, Waldmann, Herbert
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307906/
https://ncbi.nlm.nih.gov/pubmed/32058716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c00269
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