Ca(2+) Ions Promote Fusion of Middle East Respiratory Syndrome Coronavirus with Host Cells and Increase Infectivity

Fusion with, and subsequent entry into, the host cell is one of the critical steps in the life cycle of enveloped viruses. For Middle East respiratory syndrome coronavirus (MERS-CoV), the spike (S) protein is the main determinant of viral entry. Proteolytic cleavage of the S protein exposes its fusi...

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Dades bibliogràfiques
Publicat a:J Virol
Autors principals: Straus, Marco R., Tang, Tiffany, Lai, Alex L., Flegel, Annkatrin, Bidon, Miya, Freed, Jack H., Daniel, Susan, Whittaker, Gary R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2020
Matèries:
Virus-Cell Interactions
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307142/
https://ncbi.nlm.nih.gov/pubmed/32295925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00426-20
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