Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis

Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors, but only a small subset generates metastases. We conducted an in vivo genome-wide CRISPR activation screen in breast cancer patient-derived CTCs to identify genes that promote their distant metastasis in mice. Genes co...

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Bibliografiset tiedot
Julkaisussa:Science
Päätekijät: Ebright, Richard Y., Lee, Sooncheol, Wittner, Ben S., Niederhoffer, Kira L., Nicholson, Benjamin T., Bardia, Aditya, Truesdell, Samuel, Wiley, Devon F., Wesley, Benjamin, Li, Selena, Mai, Andy, Aceto, Nicola, Vincent-Jordan, Nicole, Szabolcs, Annamaria, Chirn, Brian, Kreuzer, Johannes, Comaills, Valentine, Kalinich, Mark, Haas, Wilhelm, Ting, David T., Toner, Mehmet, Vasudevan, Shobha, Haber, Daniel A., Maheswaran, Shyamala, Micalizzi, Douglas S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307008/
https://ncbi.nlm.nih.gov/pubmed/32029688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay0939
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