Identification of Subtypes of Barrett’s Esophagus and Esophageal Adenocarcinoma Based on DNA Methylation Profiles and Integration of Transcriptome and Genome Data

BACKGROUND & AIMS: Esophageal adenocarcinomas (EAC) are heterogeneous and often preceded by Barrett’s esophagus (BE). Many genomic changes have been associated with development of BE and EAC, but little is known about epigenetic alterations. We performed epigenetic analyses of BE and EAC tissues...

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Vydáno v:Gastroenterology
Hlavní autoři: Jammula, SriGanesh, Katz-Summercorn, Annalise C., Li, Xiaodun, Linossi, Constanza, Smyth, Elizabeth, Killcoyne, Sarah, Biasci, Daniele, Subash, Vinod V., Abbas, Sujath, Blasko, Adrienn, Devonshire, Ginny, Grantham, Amber, Wronowski, Filip, O’Donovan, Maria, Grehan, Nicola, Eldridge, Mathew D., Tavaré, Simon, Fitzgerald, Rebecca C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305027/
https://ncbi.nlm.nih.gov/pubmed/32032585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.01.044
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