Decoy Receptor 3 Promotes Preosteoclast Cell Death via Reactive Oxygen Species-Induced Fas Ligand Expression and the IL-1α/IL-1 Receptor Antagonist Pathway

PURPOSE: Interleukin-1α (IL-1α) is a potent cytokine that plays a role in inflammatory arthritis and bone loss. Decoy receptor 3 (DCR3) is an immune modulator of monocytes and macrophages. The aim of this study was to investigate the mechanism of DCR3 in IL-1α-induced osteoclastogenesis. METHODS: We...

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Publicado en:Mediators Inflamm
Autores principales: Peng, Yi-Jen, Peng, Ching-Tsung, Lin, Yi-Hsuan, Lin, Gu-Jiun, Huang, Shing-Hwa, Chen, Shyi-Jou, Sytwu, Huey-Kang, Cheng, Chia-Pi
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303756/
https://ncbi.nlm.nih.gov/pubmed/32587467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/1237281
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