Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits

Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic variability. Here, we conducted a genome-wide association study (GWAS) of CLZ serum concentration adjusting for known smoking habits, which is a major nongenetic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Transl Psychiatry
Prif Awduron: Smith, Robert Løvsletten, O’Connell, Kevin, Athanasiu, Lavinia, Djurovic, Srdjan, Kringen, Marianne Kristiansen, Andreassen, Ole A., Molden, Espen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303159/
https://ncbi.nlm.nih.gov/pubmed/32555152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-020-00888-1
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