Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes

The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has led to accelerated efforts to develop therapeutics, diagnostics, and vaccines to mitigate this public health emergency. A key target of these efforts is the spike (S) protein, a large trimeric class I fusion protein that is metasta...

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Publicat a:bioRxiv
Autors principals: Hsieh, Ching-Lin, Goldsmith, Jory A., Schaub, Jeffrey M., DiVenere, Andrea M., Kuo, Hung-Che, Javanmardi, Kamyab, Le, Kevin C., Wrapp, Daniel, Lee, Alison Gene-Wei, Liu, Yutong, Chou, Chia-Wei, Byrne, Patrick O., Hjorth, Christy K., Johnson, Nicole V., Ludes-Meyers, John, Nguyen, Annalee W., Park, Juyeon, Wang, Nianshuang, Amengor, Dzifa, Maynard, Jennifer A., Finkelstein, Ilya J., McLellan, Jason S.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7302215/
https://ncbi.nlm.nih.gov/pubmed/32577660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.05.30.125484
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