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The taming of PARP1 and its impact on NAD(+) metabolism
BACKGROUND: Poly-ADP-ribose polymerases (PARPs) are key mediators of cellular stress response. They are intimately linked to cellular metabolism through the consumption of NAD(+). PARP1/ARTD1 in the nucleus is the major NAD(+) consuming activity and plays a key role in maintaining genomic integrity....
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| Publicado no: | Mol Metab |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7300387/ https://ncbi.nlm.nih.gov/pubmed/32199820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.01.014 |
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