PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome

The ubiquitin ligase, Ube3a, plays important roles in brain development and functions, since its deficiency results in Angelman Syndrome (AS) while its over-expression increases the risk for autism. We previously showed that the lack of Ube3a-mediated ubiquitination of the Ca(2+)-activated small con...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Sun, Jiandong, Liu, Yan, Zhu, Guoqi, Cato, Caleb, Hao, Xiaoning, Qian, Li, Lin, Weiju, Adhikari, Rachana, Luo, Yun, Baudry, Michel, Bi, Xiaoning
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299966/
https://ncbi.nlm.nih.gov/pubmed/32555345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66790-4
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