NLRP3 inflammasome inhibition attenuates sepsis-induced platelet activation and prevents multi-organ injury in cecal-ligation puncture

Sepsis is characterized by organ dysfunction due to a dysregulated immune response to infection. Currently, no effective treatment for sepsis exists. Platelets are recognized as mediators of the immune response and may be a potential therapeutic target for the treatment of sepsis. We previously demo...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Cornelius, Denise C., Travis, Olivia K., Tramel, Robert W., Borges-Rodriguez, Marivee, Baik, Cedar H., Greer, Mallory, Giachelli, Chelsea A., Tardo, Geilda A., Williams, Jan M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299389/
https://ncbi.nlm.nih.gov/pubmed/32555710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0234039
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