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Circuits with broken fibration symmetries perform core logic computations in biological networks

We show that logic computational circuits in gene regulatory networks arise from a fibration symmetry breaking in the network structure. From this idea we implement a constructive procedure that reveals a hierarchy of genetic circuits, ubiquitous across species, that are surprising analogues to the...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Leifer, Ian, Morone, Flaviano, Reis, Saulo D. S., Andrade, José S., Sigman, Mariano, Makse, Hernán A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299331/
https://ncbi.nlm.nih.gov/pubmed/32555578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007776
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