A Single Amino Acid Substitution in the Matrix Protein (M51R) of Vesicular Stomatitis New Jersey Virus Impairs Replication in Cultured Porcine Macrophages and Results in Significant Attenuation in Pigs

In this study, we explore the virulence of vesicular stomatitis New Jersey virus (VSNJV) in pigs and its potential relationship with the virus’s ability to modulate innate responses. For this purpose, we developed a mutant of the highly virulent strain NJ0612NME6, containing a single amino acid subs...

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Bibliografiske detaljer
Udgivet i:Front Microbiol
Main Authors: Velazquez-Salinas, Lauro, Pauszek, Steven J., Holinka, Lauren G., Gladue, Douglas P., Rekant, Steven I., Bishop, Elizabeth A., Stenfeldt, Carolina, Verdugo-Rodriguez, Antonio, Borca, Manuel V., Arzt, Jonathan, Rodriguez, Luis L.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299242/
https://ncbi.nlm.nih.gov/pubmed/32587580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2020.01123
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