Hypertonic sodium lactate improves microcirculation, cardiac function, and inflammation in a rat model of sepsis

BACKGROUND: Hypertonic sodium lactate (HSL) may be of interest during inflammation. We aimed to evaluate its effects during experimental sepsis in rats (cecal ligation and puncture (CLP)). METHODS: Three groups were analyzed (n = 10/group): sham, CLP-NaCl 0.9%, and CLP-HSL (2.5 mL/kg/h of fluids for...

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Detalhes bibliográficos
Publicado no:Crit Care
Main Authors: Besnier, Emmanuel, Coquerel, David, Kouadri, Geoffrey, Clavier, Thomas, Favory, Raphael, Duburcq, Thibault, Lesur, Olivier, Bekri, Soumeya, Richard, Vincent, Mulder, Paul, Tamion, Fabienne
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7298868/
https://ncbi.nlm.nih.gov/pubmed/32546181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-020-03083-2
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