3,3′-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through repressing RhoA/ROCK1-mediated COX2/PGE(2) pathway

BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive tumors in the world. Aryl hydrocarbon receptor (AHR) has been reported to promote tumor metastasis and epithelial-mesenchymal transition (EMT) is a vital process of conferring cancer cells capabilities of migration a...

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Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: Zhu, Peiyao, Yu, Huayun, Zhou, Kun, Bai, Yu, Qi, Ruiqun, Zhang, Shuguang
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7298755/
https://ncbi.nlm.nih.gov/pubmed/32546278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01618-7
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