Prions from Sporadic Creutzfeldt-Jakob Disease Patients Propagate as Strain Mixtures

Sporadic Creutzfeldt-Jakob disease (sCJD) cases are currently classified according to the methionine/valine polymorphism at codon 129 of the PRNP gene and the proteinase K-digested abnormal prion protein (PrP(res)) isoform identified by Western blotting (type 1 or type 2). Converging evidence led to...

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Pubblicato in:mBio
Autori principali: Cassard, Hervé, Huor, Alvina, Espinosa, Juan-Carlos, Douet, Jean-Yves, Lugan, Severine, Aron, Naima, Vilette, Didier, Delisle, Marie-Bernadette, Marín-Moreno, Alba, Peran, Patrice, Beringue, Vincent, Torres, Juan Maria, Ironside, James W., Andreoletti, Olivier
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7298703/
https://ncbi.nlm.nih.gov/pubmed/32546613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00393-20
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