Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1

Chronic NF-κB activation in inflammation and cancer has long been linked to persistent activation of NF-κB–responsive gene promoters. However, NF-κB factors also massively bind to gene bodies. Here, we demonstrate that recruitment of the NF-κB factor RELA to intragenic regions regulates alternative...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ameur, Lamya Ben, Marie, Paul, Thenoz, Morgan, Giraud, Guillaume, Combe, Emmanuel, Claude, Jean-Baptiste, Lemaire, Sebastien, Fontrodona, Nicolas, Polveche, Hélène, Bastien, Marine, Gessain, Antoine, Wattel, Eric, Bourgeois, Cyril F., Auboeuf, Didier, Mortreux, Franck
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7298006/
https://ncbi.nlm.nih.gov/pubmed/32546717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16853-x
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