Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses

Emerging evidence supports the hypothesis that pathogenic protein aggregates associated with neurodegenerative diseases spread from cell to cell through the brain in a manner akin to infectious prions. Here, we show that mutant huntingtin (mHtt) aggregates associated with Huntington disease transfer...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Donnelly, Kirby M, DeLorenzo, Olivia R, Zaya, Aprem DA, Pisano, Gabrielle E, Thu, Wint M, Luo, Liqun, Kopito, Ron R, Panning Pearce, Margaret M
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7297539/
https://ncbi.nlm.nih.gov/pubmed/32463364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58499
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