GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation

Urogenital tract abnormalities are among the most common congenital defects in humans. Male urogenital development requires Hedgehog-GLI signaling and testicular hormones, but how these pathways interact is unclear. We found that Gli3(XtJ) mutant mice exhibit cryptorchidism and hypospadias due to lo...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:PLoS Genet
Κύριοι συγγραφείς: Kothandapani, Anbarasi, Lewis, Samantha R., Noel, Jessica L., Zacharski, Abbey, Krellwitz, Kyle, Baines, Anna, Winske, Stephanie, Vezina, Chad M., Kaftanovskaya, Elena M., Agoulnik, Alexander I., Merton, Emily M., Cohn, Martin J., Jorgensen, Joan S.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2020
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7297385/
https://ncbi.nlm.nih.gov/pubmed/32497091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008810
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