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Discovery of a novel hybrid from finasteride and epristeride as 5α-reductase inhibitor
Finasteride and epristeride both inhibit 5α-reductase with high potency via competitive and non-competitive mechanism, respectively. A new hybrid of finasteride and epristeride was designed as a new 5α-reductase inhibitor based on combination principles in medicinal chemistry. Human 5β-reductase was...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7296779/ https://ncbi.nlm.nih.gov/pubmed/21094046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.10.112 |
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