Intestinal Delivery of Proinsulin and IL-10 via Lactococcus lactis Combined With Low-Dose Anti-CD3 Restores Tolerance Outside the Window of Acute Type 1 Diabetes Diagnosis

A combination treatment (CT) of proinsulin and IL-10 orally delivered via genetically modified Lactococcus lactis bacteria combined with low-dose anti-CD3 (aCD3) therapy successfully restores glucose homeostasis in newly diagnosed non-obese diabetic (NOD) mice. Tolerance is accompanied by the accumu...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Cook, Dana P., Cunha, João Paulo Monteiro Carvalho Mori, Martens, Pieter-Jan, Sassi, Gabriele, Mancarella, Francesca, Ventriglia, Giuliana, Sebastiani, Guido, Vanherwegen, An-Sofie, Atkinson, Mark A., Van Huynegem, Karolien, Steidler, Lothar, Caluwaerts, Silvia, Rottiers, Pieter, Teyton, Luc, Dotta, Francesco, Gysemans, Conny, Mathieu, Chantal
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7295939/
https://ncbi.nlm.nih.gov/pubmed/32582188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01103
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