Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth

Breast cancer brain metastases (BCBM) have a 5-20 year latency and account for 30% of mortality; however, mechanisms governing adaptation to the brain microenvironment remain poorly defined. We combine time-course RNA-sequencing of BCBM development with a Drosophila melanogaster genetic screen, and...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Howe, Erin N., Burnette, Miranda D., Justice, Melanie E., Schnepp, Patricia M., Hedrick, Victoria, Clancy, James W., Guldner, Ian H., Lamere, Alicia T., Li, Jun, Aryal, Uma K., D’Souza-Schorey, Crislyn, Zartman, Jeremiah J., Zhang, Siyuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7295786/
https://ncbi.nlm.nih.gov/pubmed/32541798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16832-2
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