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HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137
The HIV-1 Vpr accessory protein induces ubiquitin/proteasome-dependent degradation of many cellular proteins by recruiting them to a cullin4A-DDB1-DCAF1 complex. In so doing, Vpr enhances HIV-1 gene expression and induces (G2/M) cell cycle arrest. However, the identities of Vpr target proteins throu...
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| Publié dans: | eLife |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
eLife Sciences Publications, Ltd
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7295576/ https://ncbi.nlm.nih.gov/pubmed/32538781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55806 |
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