Aurora-A/SOX8/FOXK1 signaling axis promotes chemoresistance via suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cells

Rationale: Cisplatin derivatives are first-line chemotherapeutic agents for epithelial ovarian cancer. However, chemoresistance remains a major hurdle for successful therapy and the underlying molecular mechanisms are poorly understood at present. Methods: RNA sequencing of organoids (PDO) establish...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Sun, Huizhen, Wang, Husheng, Wang, Xue, Aoki, Yoichi, Wang, Xinjing, Yang, Yufei, Cheng, Xi, Wang, Ziliang, Wang, Xipeng
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7295065/
https://ncbi.nlm.nih.gov/pubmed/32550913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.43811
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