PEG-coated nanoparticles detachable in acidic microenvironments for the tumor-directed delivery of chemo- and gene therapies for head and neck cancer

Background: Head and neck cancer (HNC) is a major cause of morbidity and mortality and has a poor treatment outcome. Irinotecan, a topoisomerase-I inhibitor, induces cell death by decreasing the religation of double-strand DNA. However, epithelial-mesenchymal transition (EMT), therapy resistance, an...

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Publicado en:Theranostics
Autores principales: Lo, Yu-Li, Chang, Chih-Hsien, Wang, Chen-Shen, Yang, Muh-Hwa, Lin, Anya Maan-Yuh, Hong, Ci-Jheng, Tseng, Wei-Hsuan
Formato: Artigo
Lenguaje:Inglês
Publicado: Ivyspring International Publisher 2020
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7295054/
https://ncbi.nlm.nih.gov/pubmed/32550898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.45164
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