Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes

Introduced about a century ago, suramin remains a frontline drug for the management of early-stage East African trypanosomiasis (sleeping sickness). Cellular entry into the causative agent, the protozoan parasite Trypanosoma brucei, occurs through receptor-mediated endocytosis involving the parasite...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zoltner, Martin, Campagnaro, Gustavo D., Taleva, Gergana, Burrell, Alana, Cerone, Michela, Leung, Ka-Fai, Achcar, Fiona, Horn, David, Vaughan, Sue, Gadelha, Catarina, Zíková, Alena, Barrett, Michael P., de Koning, Harry P., Field, Mark C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294092/
https://ncbi.nlm.nih.gov/pubmed/32354742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012355
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