Hypoxia-Induced Aquaporin-3 Changes Hepatocellular Carcinoma Cell Sensitivity to Sorafenib by Activating the PI3K/Akt Signaling Pathway

PURPOSE: Hypoxia-induced changes are primarily activated in patients with hepatocellular carcinoma (HCC) and long-term sorafenib exposure, thereby reducing the sensitivity to the drug. Aquaporin-3 (AQP3), a member of the aquaporin family, is a hypoxia-induced substance that affects the chemosensitiv...

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Detalles Bibliográficos
Publicado en:Cancer Manag Res
Autores principales: Malale, Kija, Fu, Jili, Qiu, Liewang, Zhan, Ke, Gan, Xiuni, Mei, Zhechuan
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove 2020
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294049/
https://ncbi.nlm.nih.gov/pubmed/32606928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S243918
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