Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress

Morphogenesis, tumor formation, and wound healing are regulated by tissue rigidity. Focal adhesion behavior is locally regulated by stiffness; however, how cells globally adapt, detect, and respond to rigidity remains unknown. Here, we studied the interplay between the rheological properties of the...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Doss, Bryant L., Pan, Meng, Gupta, Mukund, Grenci, Gianluca, Mège, René-Marc, Lim, Chwee Teck, Sheetz, Michael P., Voituriez, Raphaël, Ladoux, Benoît
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293595/
https://ncbi.nlm.nih.gov/pubmed/32444491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917555117
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