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Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress

Morphogenesis, tumor formation, and wound healing are regulated by tissue rigidity. Focal adhesion behavior is locally regulated by stiffness; however, how cells globally adapt, detect, and respond to rigidity remains unknown. Here, we studied the interplay between the rheological properties of the...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Doss, Bryant L., Pan, Meng, Gupta, Mukund, Grenci, Gianluca, Mège, René-Marc, Lim, Chwee Teck, Sheetz, Michael P., Voituriez, Raphaël, Ladoux, Benoît
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293595/
https://ncbi.nlm.nih.gov/pubmed/32444491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917555117
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