Integrin αvβ5 Internalizes Zika Virus during Neural Stem Cells Infection and Provides a Promising Target for Antiviral Therapy

We perform a CRISPR-Cas9 genome-wide screen in glioblastoma stem cells and identify integrin αvβ5 as an internalization factor for Zika virus (ZIKV). Expression of αvβ5 is correlated with ZIKV susceptibility in various cells and tropism in developing human cerebral cortex. A blocking antibody agains...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Wang, Shaobo, Zhang, Qiong, Tiwari, Shashi Kant, Lichinchi, Gianluigi, Yau, Edwin H., Hui, Hui, Li, Wanyu, Furnari, Frank, Rana, Tariq M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293422/
https://ncbi.nlm.nih.gov/pubmed/31956073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.11.020
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