Intracellular virus sensor MDA5 exacerbates vitiligo by inducing the secretion of chemokines in keratinocytes under virus invasion

Vitiligo is a disfiguring disease featuring chemokines-mediated cutaneous infiltration of autoreactive CD8(+) T cells that kill melanocytes. Copious studies have indicated that virus invasion participates in the pathogenesis of vitiligo. IFIH1, encoding MDA5 which is an intracellular virus sensor, h...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Zhuang, Tongtian, Yi, Xiuli, Chen, Jianru, Kang, Pan, Chen, Xuguang, Chen, Jiaxi, Cui, Tingting, Chang, Yuqian, Ye, Zhubiao, Ni, Qingrong, Wang, Yinghan, Du, Pengran, Li, Baizhang, Liu, Ling, Jian, Zhe, Li, Kai, Gao, Tianwen, Li, Shuli, Li, Chunying
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293308/
https://ncbi.nlm.nih.gov/pubmed/32532953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2665-z
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