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Refining LNA safety profile by controlling phosphorothioate stereochemistry
Drug discovery with phosphorothioate oligonucleotides is an area of intensive research. In this study we have controlled the stereochemistry of the phosphorothioate backbone of LNA oligonucleotides to investigate the differences in safety profile, target mRNA knock down, and cellular uptake in vitro...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7292364/ https://ncbi.nlm.nih.gov/pubmed/32530964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0232603 |
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