Defining the Threshold IL-2 Signal Required for Induction of Selective Treg Cell Responses Using Engineered IL-2 Muteins

Among all T and NK cell subsets, regulatory T (Treg) cells typically respond to the lowest concentrations of IL-2 due to elevated surface expression of the IL-2R alpha chain (IL2RA; CD25) and the high affinity IL-2 receptor (IL-2R) complex. This enhanced sensitivity forms the basis for low-dose (LD)...

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Vydáno v:Front Immunol
Hlavní autoři: Ghelani, Aazam, Bates, Darren, Conner, Kip, Wu, Min-Zu, Lu, Jiamiao, Hu, Yi-Ling, Li, Chi-Ming, Chaudhry, Ashutosh, Sohn, Sue J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7291599/
https://ncbi.nlm.nih.gov/pubmed/32582190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01106
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